[Analysis of the clinical features and the risk factors of severe adenovirus pneumonia in children].
Han Huang, Yu Chen, Lv Y., Michael Yan, Ye Deng, Wen Zhang, Y Yuan, P Xiong, F Fang, T L Liu
Abstract
The mortality rate of severe pediatric adenovirus pneumonia caused by adenovirus type 7 is high. High positive rates of adenovirus nucleic acid in nasopharyngeal swabs and mNGS in plasma or bronchoalveolar lavage fluid contribute to early diagnosis, and mNGS can also be used for serotyping. Younger children under 4 years of age, persistent fever, extensive pulmonary lesions and significantly increased inflammatory cytokines such as IL-6 are warning indicators for critical illness and poor prognosis. Relatively high dose of ribavirin combined with integrated therapeutic approaches are beneficial for prognosis.
Topics & Concepts
MedicineInternal medicineNucleic acid testAdenovirus infectionPneumoniaRibavirinBronchoalveolar lavageLogistic regressionMortality rateImmunologyLungCoronavirus disease 2019 (COVID-19)VirusDiseaseInfectious disease (medical specialty)Hepatitis C virusVirus-based gene therapy researchBiomedical and Engineering EducationCancer Research and Treatments