Electrochemical α-deuteration of amides
Shulin Ning, Cheng Wu, Lianyou Zheng, Mian Liu, Yan Zhang, Xin Che, Jinbao Xiang
Abstract
An efficient electroselective α-deuteration of amides was realized via H–D exchange under mild neutral conditions. Its utility has been well exemplified in the late-stage modification of drug molecules and transformation to β-bisdeuterated amines.
Topics & Concepts
ElectrochemistryChemistryMoleculeCombinatorial chemistryTransformation (genetics)Organic chemistryElectrodePhysical chemistryGeneBiochemistryChemical Reactions and IsotopesAsymmetric Hydrogenation and CatalysisAdvanced Synthetic Organic Chemistry