Design, synthesis and bioevaluation of novel 6-substituted aminoindazole derivatives as anticancer agents
Ngo Xuan Hoang, Van-Hai Hoang, Thi-Thu-Trang Luu, Hung N. Luu, Thien Ngo, Duong Van Hieu, Nguyen Huu Long, Le Viet Anh, Sơn Tùng Ngô, Yen Thi Kim Nguyen, Byung Woo Han, Thanh X. Nguyen, Dinh Thi Thanh Hai, Trần Thị Thu Hiền, Phuong‐Thao Tran
Abstract
value of 0.4 ± 0.3 μM in human colorectal cancer cells (HCT116). This compound also remarkably suppressed the IDO1 protein expression. In the cell-cycle studies, the suppressive activity of compound 36 in HCT116 cells was related to the G2/M cell cycle arrest. Altogether, the current findings demonstrate that compound 36 would be promising for further development as a potential anticancer agent.
Topics & Concepts
Combinatorial chemistryChemistrySeries (stratigraphy)StereochemistryBiologyPaleontologyTryptophan and brain disordersSynthesis and biological activityGenomics, phytochemicals, and oxidative stress