Enantioselective synthesis of indole derivatives by Rh/Pd relay catalysis and their anti-inflammatory evaluation
Sifeng Li, Zihao Wang, Haitao Xiao, Zhaoxiang Bian, Jun Wang
Abstract
An efficient Rh/Pd relay catalyzed intermolecular and cascade intramolecular hydroamination for the synthesis of exclusive trans 1-indolyl dihydronaphthalenols (up to 88% yield, 99% ee) is described under mild conditions. Moreover, the in silico and in vitro screening showed that the novel 1-indolyl dihydronaphthalenol products are potent lead compounds for treating inflammation disease.
Topics & Concepts
Enantioselective synthesisIndole testCatalysisCombinatorial chemistryChemistrySynergistic catalysisRelayOrganic chemistryPower (physics)Quantum mechanicsPhysicsCatalytic C–H Functionalization MethodsSynthesis of Indole DerivativesAxial and Atropisomeric Chirality Synthesis