An iron(<scp>ii</scp>)-based metalloradical system for intramolecular amination of C(sp<sup>2</sup>)–H and C(sp<sup>3</sup>)–H bonds: synthetic applications and mechanistic studies
Sandip Das, Subrata Das, Supratim Ghosh, Satyajit Roy, Monika Pareek, Brindaban Roy, Raghavan B. Sunoj, Buddhadeb Chattopadhyay
Abstract
)-H amination reactions involve a metalloradical activation mechanism, which is different from the previously reported electro-cyclization mechanism. Collectively, this study reports the discovery of a new class of metalloradical activation modes using a base metal catalyst that should find wide application in the context of medicinal chemistry, drug discovery and industrial applications.
Topics & Concepts
AminationIntramolecular forceChemistryRegioselectivityTetrazoleCatalysisCombinatorial chemistryPorphyrinAzideContext (archaeology)MoleculeStereochemistryMedicinal chemistryOrganic chemistryBiologyPaleontologySynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms