Probing the conjugation of epigallocatechin gallate with β-lactoglobulin and its <i>in vivo</i> desensitization efficiency
Xiaoning Zhang, Sining Li, Xiaoqing Shao, Meifeng Li, Yacine Hémar
Abstract
) of EGCG. The conjugation of EGCG decreased βLg's IgE combining capacity by decreasing the β-sheet component and imparted antioxidant properties by the introduction of hydroxyl groups. In addition, animal experiment results indicated that βLg induced significant changes in the levels of IgE and inflammatory cytokines, and the relative abundance of small intestinal flora, linked to the inflammatory lesions and anaphylaxis symptoms. EGCG-βLg conjugates can suppress the allergic response, attenuating serum IgE and relieving the anaphylaxis symptoms.
Topics & Concepts
Desensitization (medicine)ChemistryImmunoglobulin EIn vivoConjugateAntioxidantConjugated systemEpigallocatechin gallatePharmacologyAnaphylaxisAllergyBiochemistryImmunologyAntibodyReceptorBiologyOrganic chemistryMathematicsBiotechnologyMathematical analysisPolyphenolPolymerFood Allergy and Anaphylaxis ResearchContact Dermatitis and AllergiesAllergic Rhinitis and Sensitization