Extracellular Vesicles, Inflammation, and Cardiovascular Disease
Akbarshakh Akhmerov, Tanyalak Parimon
Abstract
Cardiovascular disease is a leading cause of death worldwide. The underlying mechanisms of most cardiovascular disorders involve innate and adaptive immune responses, and extracellular vesicles are implicated in both. In this review, we describe the mechanistic role of extracellular vesicles at the intersection of inflammatory processes and cardiovascular disease. Our discussion focuses on atherosclerosis, myocardial ischemia and ischemic heart disease, heart failure, aortic aneurysms, and valvular pathology.
Topics & Concepts
InflammationDiseaseExtracellular vesiclesExtracellularNeutrophil extracellular trapsExtracellular vesicleMedicineHeart failureMicrovesiclesImmune systemExtracellular matrixInnate immune systemPathologyCardiologyImmunologyBiologyCell biologyGeneBiochemistrymicroRNAExtracellular vesicles in diseaseCardiovascular Disease and AdiposityPulmonary Hypertension Research and Treatments