A biocompatible polyurethane fluorescent emulsion with aggregation-induced emission for targeted tumor imaging
Yangcen Ou, Xiaofei Wang, Nan He, Xiao Wang, Dan Lu, Zhen Li, Feng Luo, Jiehua Li, Hong Tan
Abstract
). Since PBA can selectively recognize and bind to sialic acid (SA) which is widely overexpressed in tumor cells, such PTP nanoparticles can be enriched in tumors and retained for longer periods due to enhanced permeability and retention (EPR) as well as active targeting effects. In addition, the PTP emulsion exhibits good biocompatibility and biosafety. Therefore, the novel PTP emulsion is promising for tumor cell imaging.
Topics & Concepts
Biocompatible materialEmulsionPolyurethaneMaterials scienceFluorescenceAggregation-induced emissionNanotechnologyChemical engineeringBiomedical engineeringComposite materialMedicineOpticsEngineeringPhysicsLuminescence and Fluorescent MaterialsNanoplatforms for cancer theranosticsPolydiacetylene-based materials and applications