Synthesis and biological evaluation of thieno[3,2-c]pyrazol-3-amine derivatives as potent glycogen synthase kinase 3β inhibitors for Alzheimer’s disease
Ning Yan, Fei Xie, L. F. Tang, Defeng Wang, Xiang Li, Chao Liu, Zhaopeng Liu
Topics & Concepts
GSK-3ChemistryNeuroprotectionNeurotoxicityNitric oxide synthasePharmacologyGSK3BGlycogen synthaseKinaseBiochemistryPhosphorylationMicrogliaHeterocyclic amineEnzymeToxicityInflammationBiologyImmunologyCarcinogenOrganic chemistryNuclear Receptors and SignalingAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases