Ruthenium complexes with chelating carboxylate-NHC ligands as efficient catalysts for C H arylation in water
Konstantin E. Shepelenko, Ksenia A. Nikolaeva, М. А. Шевченко, Yurii N. Tkachenko, Mikhail E. Minyaev, Victor M. Chernyshev
Abstract
Ruthenium(ii) complexes with chelating N-heterocyclic carbene (NHC) ligands were studied in the arylation of phenyl group in 2-phenylpyridine and 1-phenylpyrazole with aryl chlorides in water. Complexes with NHC-ligands containing a hemilabile coordinating N-carboxylatomethyl group enable fast and selective ortho-CH-diarylation in the absence of carboxylate-assisting additives.
Topics & Concepts
ChemistryCarbeneRutheniumCarboxylateChelationCatalysisArylMedicinal chemistryLigand (biochemistry)Combinatorial chemistryOrganic chemistryReceptorBiochemistryAlkylCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsN-Heterocyclic Carbenes in Organic and Inorganic Chemistry