A brain-accessible peptide modulates stroke inflammatory response and neurotoxicity by targeting BDNF-receptor TrkB-T1 specific interactome
Lola Ugalde‐Triviño, Gonzalo S. Tejeda, Gema M. Esteban-Ortega, Margarita Díaz‐Guerra
Abstract
The crucial role of TrkB-T1 in modulating microglia and astrocyte reactivity indicates that isoform-derived peptides hold promise for the development of therapies for human stroke and other excitotoxicity-associated pathologies.
Topics & Concepts
InteractomeNeurotoxicityTropomyosin receptor kinase BNeuroscienceInflammatory responseReceptorNeuroinflammationInflammationMedicineChemistryBiologyInternal medicineNeurotrophic factorsToxicityBiochemistryGeneNeuroinflammation and Neurodegeneration MechanismsAdenosine and Purinergic SignalingVagus Nerve Stimulation Research