De-epimerizing DyKAT of β-lactones generated by isothiourea-catalysed enantioselective [2 + 2] cycloaddition
Aífe Conboy, Alister S. Goodfellow, Kevin Kasten, Joanne Dunne, David B. Cordes, Michæl Bühl, Andrew D. Smith
Abstract
A dynamic kinetic asymmetric transformation that couples epimerisation with a hydrogen bond-assisted nucleophilic addition and stereodetermining ring-opening is investigated.
Topics & Concepts
Enantioselective synthesisCycloadditionChemistryCatalysisCombinatorial chemistryStereochemistryOrganic chemistryAsymmetric Synthesis and CatalysisSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms