Endovascular treatment versus medical management for basilar artery occlusion with low-to-moderate symptoms (National Institutes of Health Stroke Scale < 10)
Cyril Dargazanli, Isabelle Mourand, Mehdi Mahmoudi, Luc Poirier, Julien Labreuche, David Weisenburger‐Lile, Benjamin Gory, Sébastien Richard, Célina Ducroux, Michel Piotin, Raphaël Blanc, Ludovic Lucas, Gaultier Marnat, Mathilde Aubertin, Caroline Arquizan, Romain Bourcier, Lili Détraz, Stéphane Vannier, Maud Guillen, François Eugene, Gregory Walker, Ronda Lun, Dar Dowlatshahi, Michel Shamy, Arturo Consoli, Vincent Costalat, Bertrand Lapergue, Benjamin Maïer, Adrien Guenego, Robert Fahed
Abstract
Abstract Background: Patients with acute basilar artery occlusion (BAO) and low-to-moderate symptoms (National Institutes of Health Stroke Scale [NIHSS] < 10) are poorly represented in thrombectomy trials. Our objective is to compare thrombectomy and best medical management (BMT) in this population. Methods: We compared data of all consecutive patients presenting with an initial NIHSS < 10 and acute symptomatic BAO included in two registries. The main outcome was the proportion of patients achieving a 3-months favorable outcome (mRS 0-2 or equal to the pre-stroke value). Secondary outcomes included the proportion of patients with an excellent outcome (mRS 0-1 or equal to pre-stroke value), overall mRs distribution (shift analysis) and mortality. Effect sizes for thrombectomy versus BMT alone were calculated using binary or ordinal logistic regression model before after considering confounders using the inverse probability of treatment weighting (IPTW) propensity score method. Results: One hundred twenty-seven patients were included: sixty-four patients treated with thrombectomy (mean ± SD age: 63.4 ± 16.1) and sixty-three with BMT (mean ± SD age: 69.0 ± 14.3). There was no significant difference between groups for the rate of 3 month-favorable outcome or mortality. After propensity-score adjustment, thrombectomy was associated with a significantly higher chance of excellent outcome at 3 months (mRS 0-1 or equal to pre-stroke value; adjusted OR, 2.68; 95%CI, 1.04–6.90; p = 0.041). Conclusion: Our study suggests that thrombectomy in patients with low-to-moderate symptoms (NIHSS < 10) due to BAO does not improve the rate of favorable outcome but could lead to a higher chance of excellent outcome at 3 months. Trial Registration: ETIS Registry. http://www.clinicaltrials.govNCT03776877