225Ac-DOTATOC–Targeted Somatostatin Receptor α-Therapy in a Patient With Metastatic Neuroendocrine Tumor of the Thymus, Refractory to β-Radiation
Jingjing Zhang, Harshad Kulkarni, Richard P. Baum
Abstract
ABSTRACT: Somatostatin receptor-targeted α-therapy using α-emitter 225Ac-labeled somatostatin analogs has been suggested as a treatment option in advanced metastatic neuroendocrine tumors (NETs) failing treatment with β-emitters, such as 177Lu or 90Y. Thymus NETs are rare and usually more aggressive than other neuroendocrine tumor entities. We present here a case with β-radiation refractory metastatic thymus NET, who demonstrated an excellent therapy response (molecular and morphological remission, as well as significantly improved clinical symptoms) after 225Ac-DOTATOC-targeted α-therapy, without any adverse effects during the treatment or in the follow-up period.
Topics & Concepts
MedicineSomatostatinRefractory (planetary science)Somatostatin receptorNeuroendocrine tumorsRadiation therapyInternal medicineTargeted therapyOncologyCancer researchAdverse effectCancerBiologyAstrobiologyNeuroendocrine Tumor Research AdvancesNeuroblastoma Research and TreatmentsMyasthenia Gravis and Thymoma