Chiral phosphoric acid-catalyzed regio- and enantioselective reactions of functionalized propargylic alcohols
Chenxiao Qian, Meiwen Liu, Jianwei Sun, Pengfei Li
Abstract
Chiral phosphoric acid has been utilized for covalent activation of propargylic alcohols to act as pre-catalyst. With this activation mode, a range of highly regio- and enantioenriched heterocyclic products could be generated efficiently from racemic propargylic alcohols.
Topics & Concepts
ChemistryPhosphoric acidEnantioselective synthesisCatalysisOrganic chemistryCombinatorial chemistryAsymmetric Synthesis and CatalysisSynthetic Organic Chemistry MethodsCatalytic C–H Functionalization Methods