Plasma Lactate as a Marker for Metabolic Health
Nicholas T. Broskey, Kai Zou, G. Lynis Dohm, Joseph A. Houmard
Abstract
Blood lactate concentrations traditionally have been used as an index of exercise intensity or clinical hyperlactatemia. However, more recent data suggest that fasting plasma lactate can also be indicative of the risk for subsequent metabolic disease. The hypothesis presented is that fasting blood lactate accumulation reflects impaired mitochondrial substrate use, which in turn influences metabolic disease risk.
Topics & Concepts
HyperlactatemiaBlood lactateInternal medicineMedicineDiseaseEndocrinologyPhysiologyBlood pressureHeart rateAdipose Tissue and MetabolismMitochondrial Function and PathologyCardiovascular and exercise physiology