Sorafenib not only impairs endothelium-dependent relaxation but also promotes vasoconstriction through the upregulation of vasoconstrictive endothelin type B receptors
Qi Yu, Kun Li, Andong Zhao, Mengqian Wei, Zhenhao Huang, Yunting Zhang, Ying Chen, Ting Lian, Chuan Wang, Li Xu, Yaping Zhang, Cang‐Bao Xu, Fuqiang Liu
Topics & Concepts
VasoconstrictionMAPK/ERK pathwaySorafenibEndocrinologyInternal medicineVasodilationMesenteric arteriesDownregulation and upregulationChemistryEndothelial dysfunctionPharmacologyVascular smooth muscleEndothelin receptorReceptorKinaseMedicineBiochemistryArteryHepatocellular carcinomaSmooth muscleGeneAngiogenesis and VEGF in CancerNitric Oxide and Endothelin EffectsCoagulation, Bradykinin, Polyphosphates, and Angioedema