Interaction effect between NAFLD severity and high carbohydrate diet on gut microbiome alteration and hepatic <i>de novo</i> lipogenesis
Hyena Kang, Hyun Ju You, Giljae Lee, Seung Hyun Lee, Taekyeong Yoo, Murim Choi, Sae Kyung Joo, Jeong Hwan Park, Mee Soo Chang, Dong Hyeon Lee, Won Kim, GwangPyo Ko, Innovative Target Exploration of NAFLD (ITEN) consortium
Abstract
upregulation and of the surrogate markers of insulin resistance on NAFLD activity in the HC group. Consuming an HC diet is associated with alteration in the gut microbiome, impaired glucose homeostasis, and upregulation of hepatic DNL genes, altogether contributing to NAFLD pathogenesis.
Topics & Concepts
Nonalcoholic fatty liver diseaseBiologyLipogenesisInternal medicineMicrobiomeInsulin resistanceGut floraBody mass indexEndocrinologyGastroenterologyFatty liverPhysiologyDiabetes mellitusMedicineDiseaseImmunologyBioinformaticsLipid metabolismLiver Disease Diagnosis and TreatmentMetabolomics and Mass Spectrometry StudiesDiet and metabolism studies