Catalytic atroposelective dynamic kinetic resolutions and kinetic resolutions towards 3-arylquinolines<i>via</i>S<sub>N</sub>Ar
Mariel M. Cardenas, Mirza A. Saputra, Deane A. Gordon, Andrea N. Sanchez, Nobuyuki Yamamoto, Jeffrey L. Gustafson
Abstract
KR. On the other hand, substrates with intermediate stabilities displayed hallmarks of both DKR and KR. Finally, we also show that we can functionalize the atropisomerically enriched quinolines into pharmaceutically privileged scaffolds with minimal observed racemization.
Topics & Concepts
Kinetic energyCatalysisKinetic resolutionChemistryComputational chemistryCombinatorial chemistryPhysicsOrganic chemistryEnantioselective synthesisClassical mechanicsAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityChemical synthesis and alkaloids