Design, synthesis, and evaluation of PD-L1 degraders to enhance T cell killing activity against melanoma
Yang Liu, Mengzhu Zheng, Zhilu Ma, Yirong Zhou, Junfeng Huo, Wenbo Zhang, Yu Liu, Yuanyuan Guo, Xuechen Zhou, Hua Li, Lixia Chen
Topics & Concepts
PD-L1Flow cytometryUbiquitin ligaseCancer researchImmune systemChemistryImmunotherapyMelanomaImmune checkpointWestern blotMolecular biologyBiologyUbiquitinImmunologyBiochemistryGeneCAR-T cell therapy researchProtein Degradation and InhibitorsCancer Immunotherapy and Biomarkers