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Silencing SIRT5 induces the senescence of UCB-MSCs exposed to TNF-α by reduction of fatty acid β-oxidation and anti-oxidation

Young Hyun Jung, Chang Woo Chae, Han Seung Chang, Gee Euhn Choi, Hyun Jik Lee, Ho Jae Han

2022Free Radical Biology and Medicine25 citationsDOI

Topics & Concepts

SOD2Mesenchymal stem cellChemistrySenescenceTumor necrosis factor alphaDownregulation and upregulationOxidative stressCell biologyGene silencingSuperoxide dismutaseCancer researchImmunologyBiologyBiochemistryGeneAdipose Tissue and MetabolismAutophagy in Disease and TherapySirtuins and Resveratrol in Medicine
Silencing SIRT5 induces the senescence of UCB-MSCs exposed to TNF-α by reduction of fatty acid β-oxidation and anti-oxidation | Litcius