β(2 → 1)-β(2 → 6) branched graminan-type fructans and β(2 → 1) linear fructans impact mucus-related and endoplasmic reticulum stress-related genes in goblet cells and attenuate inflammatory responses in a fructan dependent fashion
Cynthia Fernández‐Lainez, Myrthe aan de Stegge, Luis Silva, Gabriel López‐Velázquez, Paul de Vos
Abstract
. All these benefits were fructan-structure and chain length dependent. Our study contributes to a better understanding of chemical structure-dependent beneficial effects of ITFs and GTFs on gut barrier function, which could contribute to prevention of gut inflammatory disorders.
Topics & Concepts
FructanTunicamycinEndoplasmic reticulumMucusUnfolded protein responseChemistryBiologyCell biologyBiochemistryEcologySucroseMicrobial Metabolites in Food BiotechnologyEndoplasmic Reticulum Stress and DiseaseGalectins and Cancer Biology