Topology and Contribution to the Pore Channel Lining of Plasma Membrane-Embedded Shigella flexneri Type 3 Secretion Translocase IpaB
Poyin Chen, Brian C. Russo, Jeffrey K. Duncan-Lowey, Natasha Bitar, Keith T. Egger, Marcia B. Goldberg
Abstract
Type 3 secretion systems are nanomachines employed by many bacteria, including Shigella , which deliver into human cells bacterial virulence proteins that alter cellular function in ways that promote infection. Delivery of Shigella virulence proteins occurs through a pore formed in human cell membranes by the IpaB and IpaC proteins.
Topics & Concepts
TransloconEffectorSecretionShigella flexneriType three secretion systemCell biologyChemistryTransmembrane domainTransmembrane proteinTransport proteinPhosphorylationCytosolTranslocaseLinkerBiologyFERM domainMutagenesisEndoplasmic reticulumVirulenceTopology (electrical circuits)Virulence factorChaperone (clinical)HEK 293 cellsShigellaPlasma protein bindingProtein domainBiochemistryEscherichia coli research studiesBacterial Genetics and BiotechnologyLegionella and Acanthamoeba research