Delphinidin-3-sambubioside from Hibiscus sabdariffa. L attenuates hyperlipidemia in high fat diet-induced obese rats and oleic acid-induced steatosis in HepG2 cells
Qionghua Long, Hongyan Chen, Wenhui Yang, Li Yang, Lijuan Zhang
Abstract
). Dp3-Sam up-regulated the expression of phosphorylation of AMP-activated protein kinase (pAMPK) in HFD-fed rats. Our findings indicated that Dp3-Sam possesses the potential to improve lipid metabolism dysfunction and our results offered evidence for the use of Dp3-Sam as therapy for the prevention of obesity and dyslipidemia.
Topics & Concepts
Hibiscus sabdariffaFatty acid synthaseLipid metabolismEndocrinologyHyperlipidemiaInternal medicineOleic acidCholesterol 7 alpha-hydroxylaseSteatosisLipid dropletTriglycerideBiologyBiochemistryChemistryBile acidCholesterolMedicineFood scienceDiabetes mellitusHibiscus Plant Research StudiesNatural Antidiabetic Agents StudiesPharmacology and Obesity Treatment