The Sialyl Lewis X Glycan Receptor Facilitates Infection of Subtype H7 Avian Influenza A Viruses
Minhui Guan, Alicia K. Olivier, Xiaotong Lu, William B. Epperson, Xiaojian Zhang, Lei Zhong, Kaitlyn Waters, Nataly Mamaliger, Lei Li, Feng Wen, Yizhi Jane Tao, Thomas J. DeLiberto, Xiu‐Feng Wan
Abstract
expression is not the only determinant of viral replication at either the tissue or host level. This study suggested that access to heterologous SA2,3Gal glycan receptors, including fucosylated α2,3-linked sialoglycans, shape tissue and host tropism of H7 IAVs in aquatic wild birds.
Topics & Concepts
BiologyVirologyOutbreakInfluenza A virus subtype H5N1GlycanNeuraminidaseGlycoproteinReceptorVirusMolecular biologyGeneticsInfluenza Virus Research StudiesRespiratory viral infections researchImmune Response and Inflammation