Optogenetics-enabled discovery of integrated stress response modulators
Felix Wong, Alicia Li, Satotaka Omori, Ryan S. Lach, José Núñez, Yunke Ren, Sean P. Brown, Vipul Singhal, Brent Lyda, Taivan Batjargal, Ethan Dickson, José C. Reyes, Juan Manual Uruena Vargas, Shalaka Wahane, Hahn Kim, James J. Collins, Maxwell Z. Wilson
Topics & Concepts
BiologyIntegrated stress responseDrug discoveryOptogeneticsProgrammed cell deathNeurodegenerationDNA damageUnfolded protein responseCell biologyApoptosisComputational biologyNeuroscienceBioinformaticsTranslation (biology)DiseaseGeneticsDNAPathologyMedicineMessenger RNAGeneCRISPR and Genetic EngineeringSirtuins and Resveratrol in MedicineEndoplasmic Reticulum Stress and Disease