Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B
Damijan Knez, Natalia Colettis, L.G. Iacovino, Matej Sova, Anja Pišlar, Janez Konc, Samo Lešnik, Josefina Higgs, Fabiola Kamecki, Irene C. Mangialavori, Ana Dolšak, Simon Žakelj, Jurij Trontelj, Janko Kos, Claudia Binda, Mariel Marder, Stanislav Gobec
Abstract
isomers that can discriminate between structurally related enzyme isoforms.
Topics & Concepts
ChemistryMonoamine oxidaseGene isoformStereochemistryMonoamine oxidase BIn vivoEnzymePropargylStereoselectivityMonoamine oxidase AEx vivoBiochemistryIn vitroGeneCatalysisBiologyGeneticsParkinson's Disease Mechanisms and TreatmentsSynthesis and Biological EvaluationCyclopropane Reaction Mechanisms