Anticancer gold(<scp>iii</scp>)-bisphosphine complex alters the mitochondrial electron transport chain to induce <i>in vivo</i> tumor inhibition
Jong Hyun Kim, Samuel Ofori, Sean Parkin, Hemendra J. Vekaria, Patrick G. Sullivan, Samuel G. Awuah
Abstract
inhibits the tumor growth of metastatic triple negative breast cancer and represents a new strategy to study the modulation of mitochondrial respiration for the treatment of aggressive cancer and other disease states where mitochondria play a pivotal role in the pathobiology.
Topics & Concepts
In vivoChemistryReagentElectron transport chainBiophysicsMitochondrionCell biologyCombinatorial chemistryBiochemistryBiologyOrganic chemistryGeneticsMetal complexes synthesis and propertiesAsymmetric Hydrogenation and CatalysisMetal-Organic Frameworks: Synthesis and Applications