Antitubercular activity of 2-mercaptobenzothiazole derivatives targeting <i>Mycobacterium tuberculosis</i> type II NADH dehydrogenase
Pallavi Saha, Shashikanta Sau, Nitin Pal Kalia, Deepak K. Sharma
Abstract
strain was used to examine whether C3, C4, and C11 possess NDH-2 inhibitory potential. Furthermore, cytotoxicity analysis against HepG2 displayed a safety index (SI) of >10 for C3 and C4. To get an insight into the mode of interaction at NDH-2, we have performed computational analysis of our active compounds.
Topics & Concepts
Mycobacterium tuberculosisChemistryMicrobiologyDehydrogenaseMycobacteriumBiochemistryTuberculosisEnzymeBiologyMedicinePathologyTuberculosis Research and EpidemiologyBiochemical and Molecular ResearchCancer therapeutics and mechanisms