A Four-Component Reaction for the Synthesis of Thienopyrrolediones under Transition Metal Free Conditions
Qiaoyan Xing, Fuhong Xiao, Guojiang Mao, Guo‐Jun Deng
Abstract
A three-starting-material four-component reaction strategy is described to construct thienopyrrolediones (TPDs) from the simplest raw materials, elemental sulfur, aldehydes, and β-ketoamides, under transition metal free conditions. Compared with traditional multistep reaction sequences, this process is simple, efficient, environmentally friendly, and atom-economic and has laid the foundation for further development of an easily synthesized TPD unit.
Topics & Concepts
ChemistryEnvironmentally friendlyComponent (thermodynamics)SulfurTransition metalRaw materialAtom economyAtom (system on chip)Simple (philosophy)Reaction conditionsConstruct (python library)MoleculeCombinatorial chemistryOrganic chemistryCatalysisComputer scienceThermodynamicsParallel computingEcologyPhilosophyPhysicsBiologyProgramming languageEpistemologySynthesis and Characterization of PyrrolesOrganic Chemistry Cycloaddition ReactionsSynthesis of heterocyclic compounds