Distinction between Enterococcus faecium and Enterococcus lactis by a <i>gluP</i> PCR-Based Assay for Accurate Identification and Diagnostics
Mireya Viviana Belloso Daza, Ana C. Almeida-Santos, Carla Novais, Antónia Read, Valquíria Alves, Pier Sandro Cocconcelli, Ana R. Freitas, Luísa Maria Sobreira Vieira Peixe
Abstract
gene as the best candidate, based on the phylogenomic analysis of 512 published pan-genomes, and validated the PCR assay with a comprehensive collection of 382 enterococci obtained from different sources. Further detailed analysis of clinical E. lactis strains showed that they are highly susceptible to antibiotics and lack the typical virulence markers of E. faecium but are able to cause severe human infections in immunosuppressed patients, possibly in part due to gut barrier translocation.
Topics & Concepts
Enterococcus faeciumEnterococcusMicrobiologyBiologyIdentification (biology)Human pathogenPathogenBacteriaAntibioticsGeneticsEcologyBacterial Identification and Susceptibility TestingAntimicrobial Resistance in StaphylococcusInfective Endocarditis Diagnosis and Management