SPP1 represents a therapeutic target that promotes the progression of oesophageal squamous cell carcinoma by driving M2 macrophage infiltration
Chen Wang, Yutong Li, Linhong Wang, Yu Han, Xiaohui Gao, Tiandong Li, Man Liu, Liping Dai, Renle Du
Topics & Concepts
Cancer researchGene knockdownPI3K/AKT/mTOR pathwayCD44Tumor microenvironmentInfiltration (HVAC)Downregulation and upregulationProtein kinase BCell growthMacrophage polarizationBiologyCellMedicineMacrophageCell cultureSignal transductionIn vitroCell biologyGeneGeneticsThermodynamicsTumor cellsPhysicsBiochemistryImmune cells in cancerEsophageal Cancer Research and TreatmentBone and Dental Protein Studies