Synthesis of polyacrylonitrile nanoflowers and their controlled pH-sensitive drug release behavior
Qi Lian, Han Liu, Xuefang Zheng, Dandan Jia, Chun Liu, Dongjun Wang
Abstract
experiments revealed that PAN(TBP) nanoflowers, containing BSA in buffer solution of pH 7.4, demonstrated good sustained-release and the cumulative release rate was about 83% after 260 h. The results also showed that the sustained-release from the PAN(TBP) nanoflowers best fitted the Riger-Peppas model. This study indicated that PAN(TBP) nanoflowers provided a theoretical base for the development of carriers for sustainable drug-release.
Topics & Concepts
PolyacrylonitrileMonomerAzobisisobutyronitrileChemical engineeringPolymerizationParticle sizePolymerNanogelChemistryPolymer chemistryControlled releaseAdsorptionParticle (ecology)Drug deliveryMaterials scienceNuclear chemistryOrganic chemistryEngineeringOceanographyGeologyElectrospun Nanofibers in Biomedical ApplicationsGraphene and Nanomaterials ApplicationsPolymer Nanocomposite Synthesis and Irradiation