5-Fluorouracil disrupts skeletal muscle immune cells and impairs skeletal muscle repair and remodeling
Brandon N. VanderVeen, Thomas D. Cardaci, Sarah S. Madero, Sierra J. McDonald, Brooke M. Bullard, Robert L. Price, James A. Carson, Daping Fan, E. Angela Murphy
Abstract
We examined the common chemotherapeutic 5-fluorouracil's (5FU) impact on skeletal muscle immune cells and skeletal muscle repair. 5FU monotherapy decreased body weight and muscle mass, and perturbed skeletal muscle immune cells. In addition, 5FU decreased skeletal muscle immune cells and impaired infiltration following damage contributing to disrupted muscle repair. Our results demonstrate 5FU's impact on skeletal muscle and provide a potential explanation for why some patients may be unable to properly repair damaged tissue.
Topics & Concepts
Skeletal muscleImmune systemInternal medicineLeukopeniaEndocrinologyMedicineBiologyImmunologyToxicityNutrition and Health in AgingCancer survivorship and careMuscle Physiology and Disorders