Assessment of tuberculosis disease activity in people infected with Mycobacterium tuberculosis and living with HIV: A longitudinal cohort study
Inge Kroidl, Mohamed I. M. Ahmed, Sacha Horn, Christina S. Polyak, Allahna Esber, Ajay Parikh, Leigh Anne Eller, Hannah Kibuuka, Michael Semwogerere, Betty Mwesigwa, Prossy Naluyima, Joy Mary Kasumba, Jonah Maswai, John Owuoth, Valentine Sing’oei, Eric Rono, Rebecca Loose, Michael Höelscher, Julie A. Ake, Christof Geldmacher
Abstract
Background: using a surrogate biomarker. Methods: -specific T-cell activation (defined by CD38 expression) as a well-defined surrogate marker for TB disease covering a total of 1758 person-months. Findings: -specific T cell activation were also observed in individuals with latent infection, while persistent activation was a hallmark of recurrent TB after the end of treatment. Interpretation: . Funding: This work was supported by the President's Emergency Plan for AIDS Relief via a cooperative agreement between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense [W81XWH-11-2-0174, W81XWH-18-2-0040] and by the Bundesministerium für Bildung und Forschung (BmBF) through funding of the Deutsches Zentrum für Infektionsforschung (DZIF, TTU-TB personalized medicine TTU 02_813).