Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response
Dapeng Ma, Min Yang, Qiushi Wang, Caiyu Sun, Hongbiao Shi, Weiqiang Jing, Yuxuan Bi, Xuecheng Shen, Xiaomin Ma, Zhenzhi Qin, Yueke Lin, Lihui Zhu, Yunxue Zhao, Yeping Cheng, Lihui Han
Abstract
residue. Further investigation demonstrated that methylation of cGAS by PRMT5 attenuated cGAS-mediated antiviral immune response by blocking the DNA binding ability of cGAS. Oral administration of PRMT5 inhibitors significantly protected mice from HSV-1 infection and prolonged the survival time of these infected mice. Therefore, our findings revealed an essential regulatory effect of PRMT5 on cGAS-mediated antiviral immune response and provided a promising potential antiviral strategy by modulating PRMT5.
Topics & Concepts
Protein arginine methyltransferase 5Immune systemMethyltransferaseArginineMethylationImmunityChemistryBiologyCell biologyImmunologyBiochemistryAmino acidGeneCancer-related gene regulationSex work and related issuesRNA modifications and cancer