One-Pot Synthesis of N–H-Free Pyrroles from Aldehydes and Alkynes
Lai Chen, Jingqian Huo, Helong Si, Xinyu Xu, Song Kou, Jianyou Mao, Jinlin Zhang
Abstract
The first base-mediated intermolecular cyclization of arylaldehydes and terminal arylacetylenes for the synthesis of a wide range of pyrroles in a single step has been described. The developed methodology used commercially available starting materials and tolerated a broad range of functional groups affording 2,3,5-triaryl-substituted-1H-pyrroles with good yields (up to 92% yield) under mild conditions. The possible mechanism was also discussed.
Topics & Concepts
ChemistryYield (engineering)Intermolecular forceBase (topology)Combinatorial chemistryFunctional groupOrganic chemistryMoleculeMetallurgyPolymerMaterials scienceMathematicsMathematical analysisSynthesis and Characterization of PyrrolesCatalytic C–H Functionalization MethodsSynthesis and Biological Evaluation