Simulating drug penetration during hyperthermic intraperitoneal chemotherapy
Daan R. Löke, Roxan F.C.P. Helderman, Nicolaas A.P. Franken, Arlene L. Oei, Pieter J. Tanis, Johannes Crezee, H. Petra Kok
Abstract
, are optimal for the delivery of cisplatin. Furthermore, higher temperatures and higher doses increased the effective penetration depth with 69% and 54%, respectively. We plan to extend the software developed for this study toward patient-specific treatment planning software, capable of mapping and assist in reducing heterogeneous flow patterns.
Topics & Concepts
Intraperitoneal chemotherapyMaterials sciencePenetration (warfare)DrugHyperthermic intraperitoneal chemotherapyChemotherapyPharmacologyMedicineInternal medicineCancerCytoreductive surgeryEngineeringOperations researchOvarian cancerIntraperitoneal and Appendiceal MalignanciesHepatocellular Carcinoma Treatment and PrognosisNeuroendocrine Tumor Research Advances