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Antibody Response Following a Two-Dose mRNA Vaccination Regimen, in Health Care Workers of a Tertiary Hospital in Athens, Greece

Elissavet Kontou, Kyriaki Ranellou, Dimitrios Zoulas, Anastasia Bletsa, Eirini Rompola, Evangelia‐Theophano Piperaki, Nikolaos Athanasiou, Kleio Ampelakiotou, Maria Pratikaki, Christina Stergiopoulou, Athina Argyrοpoulou, Androula Alevra, Aggeliki Megalou, Alexandra Tsirogianni

2021Journal of Personalized Medicine20 citationsDOIOpen Access PDF

Abstract

We analyzed the antibody responses of 564 hospital workers in Athens, Greece, after vaccination with two doses of the BNT162b2 (Comirnaty®; BioNTech and Pfizer) mRNA COVID-19 vaccine. A greater antibody increase was observed in women, younger age groups, previously infected individuals and personnel working in COVID-19 clinics. Notably, individuals with a prior COVID-19 infection mounted a significantly higher antibody titer following the first dose than the rest of the population; the same was true for those working in COVID-19 clinics, even without history of previous infection.

Topics & Concepts

MedicineVaccinationAntibody responseRegimenTiterAntibodyCoronavirus disease 2019 (COVID-19)Tertiary carePopulationAntibody titerHealth careImmunologyInternal medicinePediatricsDiseaseEnvironmental healthEconomicsInfectious disease (medical specialty)Economic growthSARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesViral Infections and Immunology Research