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FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma

Simone Lubrano, Rodolfo Daniel Cervantes‐Villagrana, Farhoud Faraji, Sydney I. Ramirez, Kuniaki Sato, Sendi Rafael Adame-Garcia, Adam Officer, Nadia Arang, Damiano Cosimo Rigiracciolo, Paola Y. Anguiano Quiroz, Claudia Martini, YiYu Wang, Fleur M. Ferguson, Antonietta Bacchiocchi, Ruth Halaban, Sílvia Coma, Sheri L. Holmen, Jonathan A. Pachter, Andrew E. Aplin, J. Silvio Gutkind

2025Cancer Cell36 citationsDOIOpen Access PDF

Topics & Concepts

MelanomaVemurafenibCancer researchV600EImmune systemMEK inhibitorTargeted therapyMedicineBiologyMetastatic melanomaMAPK/ERK pathwayMutationImmunologyCancerSignal transductionCell biologyInternal medicineGeneticsGeneMelanoma and MAPK PathwaysCell Adhesion Molecules ResearchCancer Mechanisms and Therapy
FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma | Litcius