FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma
Simone Lubrano, Rodolfo Daniel Cervantes‐Villagrana, Farhoud Faraji, Sydney I. Ramirez, Kuniaki Sato, Sendi Rafael Adame-Garcia, Adam Officer, Nadia Arang, Damiano Cosimo Rigiracciolo, Paola Y. Anguiano Quiroz, Claudia Martini, YiYu Wang, Fleur M. Ferguson, Antonietta Bacchiocchi, Ruth Halaban, Sílvia Coma, Sheri L. Holmen, Jonathan A. Pachter, Andrew E. Aplin, J. Silvio Gutkind
Topics & Concepts
MelanomaVemurafenibCancer researchV600EImmune systemMEK inhibitorTargeted therapyMedicineBiologyMetastatic melanomaMAPK/ERK pathwayMutationImmunologyCancerSignal transductionCell biologyInternal medicineGeneticsGeneMelanoma and MAPK PathwaysCell Adhesion Molecules ResearchCancer Mechanisms and Therapy