On the hydrolytic stability of unsymmetric platinum(<scp>iv</scp>) anticancer prodrugs containing axial halogens
Zoufeng Xu, Wai Kit Tang, Qiyuan Zhou, Shu Chen, Chi‐Kit Siu, Guangyu Zhu
Abstract
The hydrolytic stability of Pt(<sc>iv</sc>) complexes is determined by all the six ligands that coordinate to the Pt(<sc>iv</sc>) center. By appropriately choosing all the ligands during the design of Pt(<sc>iv</sc>) prodrugs, the stability of Pt(<sc>iv</sc>) prodrugs can be improved.
Topics & Concepts
ProdrugHydrolysisChemistryPlatinumHalogenChemical stabilityCombinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistryCatalysisBiochemistryAlkylMetal complexes synthesis and propertiesMagnetism in coordination complexesLanthanide and Transition Metal Complexes