<i>In vivo</i> modulation of ubiquitin chains by <i>N</i> -methylated non-proteinogenic cyclic peptides
Joseph M. Rogers, Mickal Nawatha, Betsegaw E. Lemma, Ganga B. Vamisetti, Ido Livneh, Uri Barash, Israël Vlodavsky, Aaron Ciechanover, David Fushman, Hiroaki Suga, Ashraf Brik
Abstract
-active leads, and the targeting of ubiquitin chains as a promising anti-cancer mechanism of action.
Topics & Concepts
UbiquitinChemistryCyclic peptideIn vivoStereochemistryModulation (music)BiophysicsBiochemistryPeptideBiologyPhysicsGeneticsGeneAcousticsUbiquitin and proteasome pathwaysCancer-related gene regulationProtein Degradation and Inhibitors