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Diastereodivergent synthesis of fully disubstituted spiro[indoline-3,2′-pyrrolidin]-2-ones <i>via</i> tuneable Lewis base/Brønsted base-promoted (3 + 2) cycloadditions

Ke Li, Zhipeng Zhang, Jiahui Zhu, Yuxin Wang, Jing Zhao, Er‐Qing Li, Zheng Duan

2021Organic Chemistry Frontiers19 citationsDOI

Abstract

We have developed unique base-promoted diastereoselective (3 + 2) cycloadditions. A diastereodivergent synthesis of fully disubstituted spiro[indoline-3,2′-pyrrolidin]-2-ones was realized by tuning a Lewis base/Brønsted base.

Topics & Concepts

IndolineChemistryBase (topology)Lewis acids and basesBrønsted–Lowry acid–base theoryCombinatorial chemistryStereochemistryCatalysisOrganic chemistryMathematicsMathematical analysisAsymmetric Synthesis and CatalysisSynthesis and Biological ActivitySynthetic Organic Chemistry Methods
Diastereodivergent synthesis of fully disubstituted spiro[indoline-3,2′-pyrrolidin]-2-ones <i>via</i> tuneable Lewis base/Brønsted base-promoted (3 + 2) cycloadditions | Litcius