Therapeutic inhibition of miR-802 protects against obesity through AMPK-mediated regulation of hepatic lipid metabolism
Yangyue Ni, Zhipeng Xu, Chen Li, Yuxiao Zhu, Ran Liu, Fan Zhang, Hao Chang, Maining Li, Liang Sheng, Li Zhong, Min Hou, Lin Chen, Hong You, Donald P. McManus, Wei Hu, Yinong Duan, Yü Liu, Minjun Ji
Abstract
Our study reveals the significant role of miR-802/AMPK axis in hepatic lipid metabolism and identifies the therapeutic potential of Sjp40 in treating obesity-related fatty liver.
Topics & Concepts
AMPKCD36LipogenesisLipid metabolismBiologyCell biologyChemistryEndocrinologyProtein kinase APhosphorylationBiochemistryGeneParasites and Host InteractionsVitamin D Research Studies