Depolarizing GABA <sub>A</sub> current in the prefrontal cortex is linked with cognitive impairment in a mouse model relevant for schizophrenia
Haram Kim, Lakshmi Rajagopal, Herbert Y. Meltzer, Marco Martina
Abstract
currents in the ILC contributes to cognitive impairments in scPCP mice and suggest that bumetanide, an FDA-approved drug, has potential to treat or prevent CIAS and other components of the schizophrenia syndrome.
Topics & Concepts
Prefrontal cortexNeuroscienceDepolarizationSchizophrenia (object-oriented programming)CognitionPsychologyCognitive deficitCurrent (fluid)Cognitive impairmentMedicinePsychiatryPhysicsInternal medicineThermodynamicsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain functionReceptor Mechanisms and Signaling