CTRP6 rapidly responds to acute nutritional changes, regulating adipose tissue expansion and inflammation in mice
Rotem Lahav, Yulia Haim, Nikhil S. Bhandarkar, Liron Levin, Vered Chalifa‐Caspi, Dylan C. Sarver, Ageline Sahagun, Nitzan Maixner, Barr Kovesh, G. William Wong, Assaf Rudich
Abstract
CTRP6 (C1qTNF6), a member of adiponectin gene family, regulates inflammation and metabolism in established obesity. Here, short-term high-fat feeding in mice is shown to increase adipose tissue expression of CTRP6 before changes in the expression of classical inflammatory genes occur. Conversely, CTRP6 expression in adipose tissue decreases early in the course of obesity reversal. Gain- and loss-of-function models suggest CTRP6 as a positive regulator of inflammatory cascades, and a negative regulator of adipogenesis and adipose tissue expansion.
Topics & Concepts
Adipose tissueAdipogenesisAdiponectinInflammationRegulatorEndocrinologyInternal medicineBiologyGene expressionAdipose tissue macrophagesObesityWhite adipose tissueGeneMedicineInsulin resistanceBiochemistryAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity