Structural insight into the recognition of <i>S</i> -adenosyl-L-homocysteine and sinefungin in SARS-CoV-2 Nsp16/Nsp10 RNA cap 2′-O-Methyltransferase
Panupong Mahalapbutr, Napat Kongtaworn, Thanyada Rungrotmongkol
Abstract
-adenosyl-l-methionine substrate. The atomistic binding mechanism obtained from this work paves the way for further optimizations and designs of more specific SARS-CoV-2 nsp16 inhibitors in the fight against COVID-19.
Topics & Concepts
MethyltransferaseRNAChemistryCoronavirusMethylationNucleic acidVirologyBiologyBiochemistryCoronavirus disease 2019 (COVID-19)DNAGeneMedicineDiseaseInfectious disease (medical specialty)PathologyRNA modifications and cancerTuberculosis Research and EpidemiologyCancer-related gene regulation