Litcius/Paper detail

Design, synthesis and molecular modeling of novel D-ring substituted steroidal 4,5-dihydropyrazole thiazolinone derivatives as anti-inflammatory agents by inhibition of COX-2/iNOS production and down-regulation of NF-κB/MAPKs in LPS-induced RAW264.7 macrophage cells

Xiaorui Cai, Jianfeng Cai, Ling Fang, Siqi Xu, Huide Zhu, Shuteng Wu, Yicun Chen, Shuopo Fang, Shuopo Fang

2024European Journal of Medicinal Chemistry19 citationsDOI

Topics & Concepts

ChemistryPharmacophorePharmacologyNitric oxide synthaseAnti-inflammatoryNitric oxideTumor necrosis factor alphaBiochemistryEnzymeImmunologyBiologyOrganic chemistrySynthesis and biological activityInflammatory mediators and NSAID effectsBioactive Compounds and Antitumor Agents
Design, synthesis and molecular modeling of novel D-ring substituted steroidal 4,5-dihydropyrazole thiazolinone derivatives as anti-inflammatory agents by inhibition of COX-2/iNOS production and down-regulation of NF-κB/MAPKs in LPS-induced RAW264.7 macrophage cells | Litcius