Dopaminergic Receptor Targeting in Multiple Sclerosis: Is There Therapeutic Potential?
Mikhail Melnikov, Мikhail Pashenkov, Alexey Boyко
Abstract
Dopamine is a neurotransmitter that mediates neuropsychological functions of the central nervous system (CNS). Recent studies have shown the modulatory effect of dopamine on the cells of innate and adaptive immune systems, including Th17 cells, which play a critical role in inflammatory diseases of the CNS. This article reviews the literature data on the role of dopamine in the regulation of neuroinflammation in multiple sclerosis (MS). The influence of dopaminergic receptor targeting on experimental autoimmune encephalomyelitis (EAE) and MS pathogenesis, as well as the therapeutic potential of dopaminergic drugs as add-on pathogenetic therapy of MS, is discussed.
Topics & Concepts
DopaminergicExperimental autoimmune encephalomyelitisMultiple sclerosisDopamineNeuroinflammationNeuroscienceImmune systemMedicineNeurotransmitterCentral nervous systemDopamine receptorImmunologyBiologyInflammationMultiple Sclerosis Research StudiesPeripheral Neuropathies and DisordersPsoriasis: Treatment and Pathogenesis