Photoredox synthesis of functionalized quinazolines <i>via</i> copper-catalyzed aerobic oxidative C<sub>sp2</sub>–H annulation of amidines with terminal alkynes
Vaibhav Pramod Charpe, Ayyakkannu Ragupathi, Arunachalam Sagadevan, Kuo Chu Hwang
Abstract
We demonstrate a simple CuCl-catalyzed C–H annulation of amidines with terminal alkynes to form functionalized quinazolines at RT. This photochemical method is a mild process, highly efficient, and practically applicable to the synthesis of anticancer agents.
Topics & Concepts
AnnulationChemistryCatalysisTerminal (telecommunication)Oxidative phosphorylationCombinatorial chemistryCopperOrganic chemistryTelecommunicationsBiochemistryComputer scienceCatalytic C–H Functionalization MethodsQuinazolinone synthesis and applicationsRadical Photochemical Reactions